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How to Choose a GLP-1 Provider: Your Complete Decision Guide

Published: January 15, 2025Updated: February 12, 2026Author: Top8forWeightloss Editorial TeamCategory: Guides
GLP-1weight lossprovider guidesemaglutidetirzepatide

How to Choose a GLP-1 Provider: What You Need to Know

We’ve heard the same frustrations over and over: surprise fees, slow replies, “out of stock” after you’ve already paid, and unclear insurance answers when you need them most.

Here’s a clear, no-nonsense way to pick a provider who will actually show up for you: predictable costs, real medical support, and honest expectations on coverage and timelines.

The provider you pick becomes part of your healthcare team, so it’s worth slowing down long enough to make a confident choice.

There are a lot of providers out there now, and they're not all the same. Some are great, some are okay, and some you should probably avoid. We're going to walk you through how to tell the difference.

What Should You Look For in a Provider?

Before you start comparing providers, it helps to know what actually matters. Every person's situation is different, so what's perfect for someone else might not be right for you.

Maybe you're on a tight budget and need the most affordable option. Maybe you have insurance that covers weight loss medications, so cost isn't your main concern. Or maybe you're someone who needs a lot of support and guidance throughout the process.

Here's what to think about:

Cost

This is usually the first thing people think about, and it makes sense. Your monthly cost can range from $25 to over $1,000 depending on whether you have insurance, what medication you choose, and which provider you pick.

The cheapest option isn't always the best, though. You might find a provider that charges $200 a month, but then discover they don't offer much support, or they have hidden fees that pop up later.

You want to find a balance between what you can afford and what you're actually getting for that money.

Support

GLP-1 medications are powerful drugs, and you're going to have questions. What happens if you feel nauseous at 10 PM on a Saturday? What if you miss a dose because you forgot?

A good provider will have real healthcare providers you can actually talk to. Not just a chatbot that gives generic answers, or an email form that takes three days to get a response. They should check in with you regularly and help you figure out what's working and what isn't.

Think about it: if you're spending hundreds of dollars a month, you deserve real support, not just a prescription in the mail.

Insurance

If your insurance covers weight loss medications, that can make a huge difference in cost. We're talking about the difference between paying $25-$150 a month versus $800-$1,400 a month.

But insurance coverage is tricky. Even if a provider says they "accept insurance," that doesn't mean your specific plan will cover GLP-1 medications for weight loss. Some insurance plans only cover them if you have diabetes. Some require you to try other weight loss methods first. Some don't cover them at all.

You need to call your insurance company yourself and ask specifically about coverage for Wegovy®, Zepbound®, or Ozempic® for weight loss. Don't just trust what the provider tells you.

Safety

This should be non-negotiable. Your provider should have licensed doctors, nurse practitioners, or physician assistants who actually review your health information before prescribing.

They should ask about your medical history. Do you have any heart problems? Any kidney issues? Any history of pancreatitis? They should ask about any medications you're taking that might interact with GLP-1 medications.

If they're just having you fill out a form online and automatically approving everyone who checks the right boxes, that's a red flag. Real medical care requires real medical oversight.

trophy iconTop Choice
1
MEDVi Logo
9
EXCELLENT

US Board-Certified Clinician Prescribed$120 OFF + Free ShippingPricing starts at $179/month

Accepts Insurance: Yes
Insurance Required: No
Weightloss Program Included: Yes
GLP-1 Brands Offered: Wegovy®, Ozempic®
Clinician Support: Unlimited 24/7 support

Join 100,000+ MEDVi patients and lose an average of 18% of your body weight. 93% kept the weight off for good. Find Doctor-Approved GLP-1 Medication with weight loss guaranteed or your money back.


Read Icon   Read ReviewVisit Site

Looking for a provider that checks all these boxes? Compare top-rated options above.

The 5 Things Every Smart Shopper Checks

After looking at hundreds of provider reviews and talking to people who've been through this, we found five things that really separate the good providers from the bad ones.

Use this as your checklist when you're comparing options.

1. Are They Actually Licensed?

This might seem obvious, but you'd be surprised how many people don't check. When you're dealing with prescription medications, especially ones as powerful as GLP-1 drugs, you need to make sure you're working with legitimate, licensed professionals.

Your provider should have:

  • Licensed healthcare providers (doctors, nurse practitioners, or physician assistants) who actually review prescriptions before they're sent out. These should be real people with real medical licenses, not just names on a website.
  • If they offer compounded medications, they should use a state-licensed pharmacy. Compounding pharmacies need to be licensed by the state they operate in, and you should be able to verify this.
  • Clear credentials displayed on their website. You shouldn't have to dig for this. Look for an "About Us" or "Our Team" section that shows who the healthcare providers are, where they went to school, and which states they're licensed in.
  • No FDA warnings or regulatory actions against them. You can check the FDA's website for any warnings or actions taken against providers or pharmacies.

Here's a tip: if you can't easily find licensing information on their website, or if they get defensive when you ask about credentials, that's a bad sign. Legitimate providers are proud of their qualifications and make them easy to find.

2. Are They Honest About Pricing?

Pricing can be confusing because there are so many different fees that can add up. You might see a provider advertising "Starting at $179/month!" but then discover that's just for the medication.

Before you know it, you're paying $300-$400 a month instead of the $179 you thought you'd be paying. A good provider will tell you upfront:

  • The consultation fee, if there is one. Some providers charge $50-$200 upfront. Others fold it into the monthly cost.
  • Monthly medication cost. Brand name medications run $800-$1,400/month without insurance. Compounded versions are typically $200-$600/month.
  • Dose-based price increases are common. Many providers start you low and gradually increase, and some charge more at higher doses. Ask how the price changes at each step.
  • Shipping adds $10-$30 per delivery at some providers, while others include it.
  • Follow-up visits may or may not be bundled in. Some providers include regular check-ins in the monthly cost, others charge per visit.
  • Ask specifically about membership fees or hidden recurring charges. Some providers layer a monthly membership fee on top of medication and consultation costs.

If they can't give you a clear answer when you ask "What's the total cost for the first month, including everything?" that's a problem. A good provider will be able to give you a clear breakdown of all costs.

3. Do They Actually Provide Medical Support?

GLP-1 medications aren't like ordering vitamins online. These are prescription drugs that can have side effects like nausea, vomiting, diarrhea, constipation, stomach pain, and in rare cases, more serious issues.

You need real medical oversight, not just someone who sends you medication in the mail and hopes for the best. A good provider will:

  • Do an actual medical consultation before prescribing (not just have you fill out a form). This should be a real conversation with a healthcare provider, either over video, phone, or in person.
  • Check in with you regularly to see how you're doing. They should ask how you're feeling, whether you're experiencing side effects, and whether the medication is working.
  • Adjust your dose if needed based on how you're responding. If you're not losing weight, they might increase your dose. If you're having bad side effects, they might decrease it.
  • Have healthcare providers you can actually talk to if you have questions or concerns. This means real people you can reach by phone, email, or messaging. Not just a chatbot.
  • Give you clear guidance on what side effects to watch for and when to seek help. They should tell you which side effects are normal and which ones are concerning.
  • Monitor your progress and health markers over time. The best providers don't just care about whether you're losing weight. They care about your overall health.

The best providers don't just write you a prescription and send you on your way. They become part of your healthcare team and help you through the whole process.

4. How Do They Handle Insurance and Payment?

Insurance coverage can make a huge difference in what you pay. We're talking about the difference between $25-$150 a month with insurance versus $800-$1,400 a month without it.

But insurance is complicated, and there are a lot of things you need to understand:

  • Do they accept your insurance? Even if they say yes, your specific plan might not cover GLP-1 medications for weight loss. "Accepts insurance" and "your plan covers this" are two different things.
  • Your copay if insurance does cover it. This can range from $25 to $500 depending on your plan, so get the number before you commit.
  • Your out-of-pocket cost if it doesn't. Brand name medications run $800-$1,400/month without coverage. Compounded versions are typically $200-$600/month.
  • Manufacturer savings programs can bring costs down significantly. Novo Nordisk (Wegovy, Ozempic) and Eli Lilly (Zepbound) both offer savings cards. Ask if the provider helps you access these.
  • Payment plans or financing, if upfront cost is a barrier. Some providers let you spread payments monthly instead of paying everything at once.

Important: Always call your insurance company yourself to verify coverage. Don't just trust what the provider tells you. Call the number on the back of your insurance card and ask specifically about coverage for Wegovy®, Zepbound®, or Ozempic® for weight loss.

5. Do They Help You Long-Term?

Weight loss isn't a one-time thing. It's a journey that can take months or even years. And here's something important to understand: if you stop taking GLP-1 medications, you'll likely gain the weight back.

Studies show that most people regain most of their weight within a year of stopping the medication. That's why you need a provider who's in it for the long haul, not just someone who gives you a prescription and disappears.

A good provider will:

  • Offer programs that include lifestyle coaching, not just medication. The medication helps, but it works best when combined with healthy eating, regular exercise, and behavior changes.
  • Help you maintain your weight loss after you reach your goals. Once you've lost the weight, you need to keep it off. This might mean staying on a maintenance dose of the medication.
  • Provide resources for nutrition, exercise, and behavior change. This might include meal plans, recipes, workout guides, or tips for dealing with emotional eating.
  • Have options for community or peer support. Some people find it helpful to connect with others who are going through the same journey.
  • Be clear about what happens if you need to stop or pause treatment. Life happens. A good provider will have a plan for this and help you understand what to expect.

Research shows that medication combined with lifestyle changes works way better than medication alone. Look for providers who understand this and offer comprehensive programs, not just pills.

See Providers That Check These Boxes

Now that you know the 5 critical factors, here are top-rated providers that meet these standards:

trophy iconTop Choice
1
MEDVi Logo
9
EXCELLENT

US Board-Certified Clinician Prescribed$120 OFF + Free ShippingPricing starts at $179/month

Accepts Insurance: Yes
Insurance Required: No
Weightloss Program Included: Yes
GLP-1 Brands Offered: Wegovy®, Ozempic®
Clinician Support: Unlimited 24/7 support

Join 100,000+ MEDVi patients and lose an average of 18% of your body weight. 93% kept the weight off for good. Find Doctor-Approved GLP-1 Medication with weight loss guaranteed or your money back.


Read Icon   Read ReviewVisit Site
SC
Sesame Care Logo
9
EXCELLENT

Brand-Name GLP-1s + Insurance AcceptedLabs Included + Same-Day AppointmentsPricing starts at $25/month*

Accepts Insurance: Yes (for GLP-1 medications)
Insurance Required: No
Weightloss Program Included: Yes, Success by Sesame
GLP-1 Brands Offered: All Major Brands including Wegovy®, Ozempic®, Zepbound®, Rybelsus® + more
Clinician Support: Video visits & unlimited messaging
Hidden Fees: $99/mo membership (covers visits, messaging, labs)

Sesame accepts insurance and has one of the largest selections of brand-name GLP-1s, so Wegovy®, Ozempic®, or Zepbound® could cost as low as $25/month if you're covered. Unlike most telehealth providers, you pick your own doctor from their network and can book same-day appointments. LegitScript certified with labs included at Quest Diagnostics locations. BBB accredited and their upfront transparent pricing chart compares insured vs cash pay medication prices.<br><br>*Price shown applies to branded medication covered by insurance. Cash pay options start at $199/mo for first 2 months, then $349/mo.


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These providers offer licensed healthcare, transparent pricing, and comprehensive support.

Brand Name vs. Compounded: What's the Real Difference?

This is super important to understand! There are two main types of GLP-1 medications, and they're very different.

Brand Name Medications (Ozempic®, Wegovy®, Zepbound®, Saxenda®)

What they are: These are made by big drug companies (Novo Nordisk makes Ozempic/Wegovy/Saxenda, Eli Lilly makes Zepbound) and have been tested a lot by the FDA to make sure they're safe and work well.

Good things about them:

  • Made under super strict quality rules
  • Tested in big studies with lots of people
  • Same dose every time (consistent)
  • Insurance usually covers them (if you qualify)
  • Companies offer savings cards to help with costs

Not so good things:

  • Expensive without insurance ($800-$1,400/month)
  • Insurance doesn't always cover them
  • Have experienced supply shortages in the past

Compounded Medications

What they are: These are made by special pharmacies that mix the same ingredients (semaglutide, tirzepatide, or liraglutide) but add other stuff to make custom versions.

Good things about them:

  • Usually cheaper ($200-$600/month depending on the medication)
  • Available through many providers
  • May be available when brand names are sold out
  • Made by licensed compounding pharmacies

Things to consider:

  • FDA approval: Compounded medications are not FDA-approved finished products. They're prepared by licensed compounding pharmacies for individual patients and have not undergone the same regulatory review as brand-name medications.
  • Pharmacy selection: Since different compounding pharmacies may prepare medications slightly differently, it's important to work with a provider who uses a licensed, reputable compounding pharmacy.
  • Insurance coverage: Most insurance plans don't cover compounded medications, so you'll typically pay out of pocket.
  • Availability: Availability may vary by provider and state regulations.

Bottom line: Compounded medications can be a more affordable option if you don't have insurance coverage for brand name medications. Many providers offer both brand name and compounded options, so you can choose what works best for your budget and needs.

Always discuss your options with your healthcare provider, clinician, or medical team to determine the best choice for your individual situation.

Providers That Offer Both Options

Many top providers offer both brand name and compounded medications, giving you flexibility to choose what works best for your situation:

SC
Sesame Care Logo
9
EXCELLENT

Brand-Name GLP-1s + Insurance AcceptedLabs Included + Same-Day AppointmentsPricing starts at $25/month*

Accepts Insurance: Yes (for GLP-1 medications)
Insurance Required: No
Weightloss Program Included: Yes, Success by Sesame
GLP-1 Brands Offered: All Major Brands including Wegovy®, Ozempic®, Zepbound®, Rybelsus® + more
Clinician Support: Video visits & unlimited messaging
Hidden Fees: $99/mo membership (covers visits, messaging, labs)

Sesame accepts insurance and has one of the largest selections of brand-name GLP-1s, so Wegovy®, Ozempic®, or Zepbound® could cost as low as $25/month if you're covered. Unlike most telehealth providers, you pick your own doctor from their network and can book same-day appointments. LegitScript certified with labs included at Quest Diagnostics locations. BBB accredited and their upfront transparent pricing chart compares insured vs cash pay medication prices.<br><br>*Price shown applies to branded medication covered by insurance. Cash pay options start at $199/mo for first 2 months, then $349/mo.


Read Icon   Read ReviewVisit Site

Red Flags: What to Watch Out For

Most providers are legitimate and want to help you, but there are some warning signs you should know about.

If you see any of these, it's probably best to look elsewhere:

  • No medical consultation required: If they'll prescribe medication without actually talking to you or reviewing your health, that's dangerous. Real providers need to know about your medical history, other medications you're taking, and any health conditions you have.
  • They promise you'll lose a certain amount of weight: No medication can guarantee specific results. Everyone's body responds differently.
  • They pressure you to decide right away: Legitimate providers give you time to think about it and ask questions. If someone is pushing you to sign up immediately with "limited time offers," that's a red flag.
  • Unclear or hidden pricing: If they won't tell you the total cost upfront, or if you discover fees you didn't know about later, that's a problem.
  • You can't verify their licensing: If you can't find information about their healthcare providers' licenses, or if they avoid questions about credentials, don't proceed.
  • They claim compounded drugs are FDA-approved: This is misleading. Only the active ingredients in compounded medications are FDA-approved. The finished compounded product itself is not FDA-approved.
  • No way to contact them: You need to be able to reach your provider if you have questions or concerns. If there's no phone number, no email, no way to contact customer support, that's a problem.
  • They want payment before the consultation: Most legitimate providers do the consultation first, then charge you. If they want you to pay upfront before you even talk to a healthcare provider, that's unusual.

If you see any of these red flags, trust your instincts and look for a different provider. There are plenty of legitimate options out there. You don't need to take risks with your health or your money.

Questions You Should Ask Before Signing Up

Don't be shy about asking questions. A good provider will welcome your questions and answer them clearly. Here are the questions you should ask:

About Credibility and Safety

  • Are your prescribers licensed healthcare providers? In which states are they licensed?
  • What pharmacy do you use for compounded medications? Is it licensed?
  • Can you provide proof of licensing and credentials?
  • Have you received any FDA warnings or regulatory actions?
  • Who owns the company? Is that information available on your website?

About Costs and Pricing

  • What is the total cost for the first month, including all fees?
  • Are there any hidden fees I should know about?
  • Do you accept my insurance? What would my copay be?
  • What happens to the cost if my dose increases?
  • What is your refund or cancellation policy?
  • Are there any membership fees or recurring charges beyond the medication cost?

About Support and Care

  • What kind of medical support do you provide?
  • How quickly can I reach a healthcare provider if I have questions?
  • Do you offer ongoing check-ins and dose adjustments?
  • What happens if I experience side effects?
  • Do you provide lifestyle coaching or just medication?
  • What kind of monitoring do you do? Do you check my progress regularly?

About Medications

  • Do you offer brand name or compounded medications (or both)?
  • If compounded, what pharmacy prepares the medication?
  • Can you provide a certificate of analysis or lot number for my medication?
  • How do you ensure medication quality and safety?
  • What happens if there's a problem with my medication?

Take notes on their answers. If they can't or won't answer these questions clearly, that's a sign you should look elsewhere.

What People Wish They'd Known

We've talked to a lot of people who've gone through this process. Here's what they wish someone had told them:

Sarah, 34: "I went with the cheapest option without checking if they had good support. When I had questions about side effects, it took days to get a response.

I ended up switching to a more expensive provider, but the peace of mind is worth it. You get what you pay for, and when it comes to your health, that matters."

Michael, 42: "I almost didn't start because I thought I couldn't afford it. But when I called my insurance, they actually covered Wegovy.

Always check your insurance first. You might be surprised. Even if they don't cover it, there are manufacturer savings programs that can help."

Jennifer, 29: "The provider I chose included nutrition coaching and regular check-ins. That support made all the difference.

The medication helps, but the lifestyle changes are what made it stick. Look for providers who offer more than just a prescription."

The common thread? People who took time to research, ask questions, and choose providers that matched their needs had better experiences and better results. Don't rush this decision.

Compare All Top Provider Options

Now that you know what to look for, here are all the top-rated providers to compare side-by-side:

trophy iconTop Choice
1
MEDVi Logo
9
EXCELLENT

US Board-Certified Clinician Prescribed$120 OFF + Free ShippingPricing starts at $179/month

Accepts Insurance: Yes
Insurance Required: No
Weightloss Program Included: Yes
GLP-1 Brands Offered: Wegovy®, Ozempic®
Clinician Support: Unlimited 24/7 support

Join 100,000+ MEDVi patients and lose an average of 18% of your body weight. 93% kept the weight off for good. Find Doctor-Approved GLP-1 Medication with weight loss guaranteed or your money back.


Read Icon   Read ReviewVisit Site
SC
Sesame Care Logo
9
EXCELLENT

Brand-Name GLP-1s + Insurance AcceptedLabs Included + Same-Day AppointmentsPricing starts at $25/month*

Accepts Insurance: Yes (for GLP-1 medications)
Insurance Required: No
Weightloss Program Included: Yes, Success by Sesame
GLP-1 Brands Offered: All Major Brands including Wegovy®, Ozempic®, Zepbound®, Rybelsus® + more
Clinician Support: Video visits & unlimited messaging
Hidden Fees: $99/mo membership (covers visits, messaging, labs)

Sesame accepts insurance and has one of the largest selections of brand-name GLP-1s, so Wegovy®, Ozempic®, or Zepbound® could cost as low as $25/month if you're covered. Unlike most telehealth providers, you pick your own doctor from their network and can book same-day appointments. LegitScript certified with labs included at Quest Diagnostics locations. BBB accredited and their upfront transparent pricing chart compares insured vs cash pay medication prices.<br><br>*Price shown applies to branded medication covered by insurance. Cash pay options start at $199/mo for first 2 months, then $349/mo.


Read Icon   Read ReviewVisit Site
DM
Direct Meds Logo
9.6
EXCELLENT

Compounded GLP-1 with 1:1 Medical Support$100 OFF First Month + Free 2-Day ShippingPricing starts at $147/month*

Accepts Insurance: No
Insurance Required: No
Weightloss Program Included: Yes
GLP-1 Brands Offered: Compounded Semaglutide & Tirzepatide
Clinician Support: Dedicated patient support team
Hidden Fees: No membership or hidden fees

Full purity lab results posted right on their websites FAQ is the kind of transparency you find with DirectMeds. LegitScript certified and an in-house medical director provides oversight you can verify. Pricing stays locked month after month with injection or oral drop options. 100k+ happy customers, 4.8-star TrustPilot rating, and your money back if you don't qualify. *Price shown applies to the first month, after $100 off for non-injectable sublingual oral medication, $247/mo thereafter. Semaglutide starts at $197/month for the first month, $297/mo thereafter.


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We maintain partnerships with the providers featured on this page and earn a commission upon purchase. These relationships may affect which offers are presented and their placement. Advertiser Disclosure.

Your Step-by-Step Guide to Choosing

Ready to make your choice? Here's a simple way to think through it:

Step 1: Figure Out What Matters Most to You

What's your priority? Is it cost? Support? Insurance coverage? Convenience?

Be honest with yourself. There's no wrong answer, but knowing what matters most will help you evaluate providers through the right lens.

Step 2: Check Your Insurance First

Before you do anything else, call your insurance company. Ask specifically about coverage for Wegovy®, Zepbound®, or Ozempic® for weight loss.

Get your copay amount in writing. Even if a provider says they accept insurance, your specific plan might not cover weight loss medications. Always verify yourself.

Step 3: Research 3-5 Providers

Don't just pick the first one you find. Compare at least 3-5 providers using the five factors we talked about above.

Look at their websites, read reviews (but take them with a grain of salt), and see what they offer.

Step 4: Ask Your Questions

Use the question checklist we provided above. Call or chat with each provider. Take notes on their responses.

How quickly do they respond? Do they answer your questions clearly? Do they seem knowledgeable and helpful?

Step 5: Check for Red Flags

Review your notes against the red flags list. If you see any warning signs, remove that provider from consideration.

Trust your instincts. If something feels off, it probably is.

Step 6: Compare Total Costs

Calculate the total cost for at least 3 months, not just the first month. Include all fees, shipping, and follow-ups.

The cheapest first month might not be the cheapest long-term if there are hidden fees or if the price goes up.

Step 7: Trust Your Instincts

Which provider feels right? Which one answered your questions clearly? Which one made you feel confident and supported?

Sometimes the best choice isn't the cheapest or the most popular. It's the one that feels like the right fit for you.

Step 8: Start with a Trial Period If Possible

If you can, start with a shorter commitment. See how the provider handles your questions, how the medication works for you, and how you feel about the relationship.

You can always commit longer once you know it's a good fit.

Common Questions About Choosing a Provider

How do I know if a provider is legitimate?

Check for licensed healthcare providers, state-licensed pharmacy (if offering compounded meds), clear credentials on their website, positive verified reviews, and no FDA warnings. Legitimate providers are transparent about their licensing and credentials. If you can't easily find this information, that's a red flag.

Should I choose brand name or compounded medications?

This depends on your insurance coverage, budget, and preferences. Brand-name medications are FDA-approved finished products and may be covered by insurance. Compounded medications are not FDA-approved but are typically more affordable cash-pay options. Discuss both paths with your healthcare provider to see what makes sense for your situation.

What should I do if I see red flags?

Trust your instincts. If a provider shows red flags like no medical consultation, pressure tactics, or unclear pricing, walk away. There are plenty of legitimate providers. You don't need to take risks with your health or your money.

How much should I expect to pay?

Costs vary widely. With insurance coverage, you might pay $25-$500/month. Without insurance, brand name medications cost $800-$1,400/month, while compounded versions typically cost $200-$600/month. Always get the total cost including all fees, not just the medication price.

What kind of support should I expect?

You should have access to licensed healthcare providers for questions, regular check-ins, dose adjustments, guidance on side effects, and ideally, lifestyle coaching. The best providers offer comprehensive support, not just prescriptions. They become part of your healthcare team.

Can I switch providers if I'm not happy?

Yes, but check the cancellation policy first. Some providers require notice or have fees. Your medical records can typically be transferred to a new provider. It's better to switch than to stay with a provider you don't trust or who isn't meeting your needs.

Where This Information Comes From

We want you to trust what you read here, so here are the studies and sources we used:

  1. U.S. Food and Drug Administration. "FDA Clarifies Policies for Compounders as National GLP-1 Supply Begins to Stabilize." Published May 2025. Available at: fda.gov
  2. U.S. Food and Drug Administration. "FDA's Concerns with Unapproved GLP-1 Drugs Used for Weight Loss." Published September 2025. Available at: fda.gov
  3. Richards R, Richards D, McVay MA, et al. Semaglutide and Tirzepatide in a Remote Weight Management Program: Real-World Effectiveness and Engagement. JMIR Formative Research. 2025;9:e81912. doi:10.2196/81912
  4. Wilding JPH, Batterham RL, Davies M, et al. Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension. Diabetes, Obesity and Metabolism. 2022;24(8):1553-1564. doi:10.1111/dom.14725

Other helpful resources:

  • U.S. Food and Drug Administration. Drug Approvals and Databases. Available at: fda.gov/drugs
  • Institute for Clinical and Economic Review (ICER). Semaglutide and Tirzepatide for Obesity: Effectiveness and Value. Published September 2025. Available at: icer.org

Last updated: February 12, 2026. Prices, insurance coverage, and medication availability change all the time. Always double-check with your doctor and insurance company!

†Ozempic® (semaglutide) is a prescription-only subcutaneous injection that has not been approved by the FDA as safe and effective to treat obesity and overweight; however, studies have shown that it may be associated with weight loss in individuals with type 2 diabetes.

††Wegovy® (semaglutide) is a prescription-only subcutaneous injection that helps to reduce excess body weight and maintain weight reduction in adults with obesity and adults with overweight and at least one weight-related condition.

†††Zepbound® (tirzepatide) is a prescription-only subcutaneous injection that, when combined with a reduced-calorie diet and exercise, helps to reduce excess body weight and maintain weight reduction in adults with obesity or overweight and at least one weight-related condition, as well as moderate to severe obstructive sleep apnea in adults with obesity.

††††Generic Liraglutide (liraglutide injection) is a prescription-only subcutaneous injection that, as an adjunct to diet and exercise, helps to improve glycemic control in adults and pediatric patients aged 10 years and older with type 2 diabetes mellitus.