TrumpRx launched on February 6, 2026, as a government website that connects people to manufacturer discount programs for 43 prescription medications. The pricing uses a "most-favored-nation" model, matching what comparable countries pay for the same drugs.
TrumpRx is not a pharmacy, though. It does not sell medications, fill prescriptions, or provide medical care. For most of the 43 listed drugs, the site generates manufacturer coupons you print and bring to a retail pharmacy. Only eight medications link directly to a manufacturer's online pharmacy for purchase.
Five manufacturers participate: Novo Nordisk, Eli Lilly, Pfizer, AstraZeneca, and EMD Serono. The deals between the government and these manufacturers are confidential, so the full terms are not public.
GLP-1 Medications on TrumpRx
Four weight-related medications appear on TrumpRx. All are FDA-approved brand-name drugs. Compounded versions are not part of this program.
Medication
TrumpRx Price
List Price
Wegovy® Pill
$149/mo*
$1,349/mo
Wegovy® Pen (injection)
$199/mo**
$1,349/mo
Ozempic®
$199/mo
$1,028/mo
Zepbound®
$299-$449/mo***
$1,087/mo
*Wegovy pill: $149/mo for the first two months, then $299/mo ongoing (per NovoCare, verified March 2026). **Wegovy pen: $199/mo for the first two months, then $349/mo ongoing. ***Zepbound pricing varies by dose through LillyDirect. These cash-pay prices match what NovoCare and LillyDirect offer directly. Sources: trumprx.gov, NovoCare.com, KFF Issue Brief (Feb 24, 2026).
The Part That Matters: You Still Need a Prescription
TrumpRx handles the discount. It does not handle the prescription. Every medication on the site requires a valid Rx from a licensed provider before you can use any of these prices.
That means the path looks like this: find a provider, get evaluated, receive a prescription if medically appropriate, and then use TrumpRx pricing at checkout or at the pharmacy. The discount is the last step, not the first one.
For GLP-1 medications specifically, your provider options include your primary care doctor, an endocrinologist, or a telehealth platform that prescribes brand-name weight loss medications. Not every telehealth provider carries brand-name GLP-1s, though. Many focus on compounded versions instead. If you want to use TrumpRx pricing, confirm that your provider prescribes the FDA-approved brand-name medication you want before signing up.
Comparing GLP-1 Providers?
Whether you go the brand-name route through TrumpRx or explore compounded options, the right provider and program matter. These offer licensed clinical care with transparent pricing.
Are These Prices Actually New?
Mostly, yes. The KFF analyzed archived GoodRx listings and found that 2025 prices for most TrumpRx drugs were higher than what the program now offers. Manufacturers announced anticipated discounts in late 2025, and both TrumpRx and the manufacturers' own programs (NovoCare, LillyDirect) rolled out the lower prices around the same time in early 2026.
So TrumpRx didn't just slap a government label on existing discounts. The deals between the administration and the five participating manufacturers produced genuinely lower cash-pay prices. What TrumpRx adds beyond the manufacturer portals is a single front door. NovoCare handles Novo Nordisk drugs. LillyDirect handles Lilly drugs. TrumpRx puts them in one place, and the government branding may build more trust for people who would not have visited a pharmaceutical company's discount site on their own.
That said, if you're already buying through NovoCare or LillyDirect at their current prices, TrumpRx will not save you additional money. The prices are the same across all three channels.
Telehealth Providers Using These Prices
Some telehealth platforms that prescribe brand-name GLP-1s have aligned their pricing with NovoCare and LillyDirect. Ro, for example, states on their website that cash-pay prices match TrumpRx, NovoCare, and LillyDirect directly. If your provider already routes prescriptions through a manufacturer program, TrumpRx won't change your out-of-pocket cost.
What TrumpRx Does Not Cover
Before planning around TrumpRx pricing, there are several limitations to understand.
Cash-Pay Only
TrumpRx discounts are only for people paying out of pocket. If you use insurance, these prices do not apply. More importantly, money spent through TrumpRx does not count toward your insurance deductible or out-of-pocket maximum. That means using TrumpRx instead of running the prescription through insurance could cost you more in the long run if you have a plan that would eventually cover the medication after meeting your deductible.
Not Available Everywhere
California and Massachusetts prohibit prescription drug coupons when no generic alternative exists. Since no generic GLP-1 medications are available, TrumpRx coupons cannot be used in those two states. If you live in CA or MA, this program is not an option for you.
No Compounded Medications
TrumpRx lists only FDA-approved brand-name medications. Compounded semaglutide and compounded tirzepatide (which are not FDA-approved) are not part of this program. If you're currently using or considering compounded GLP-1 medications through a telehealth provider, TrumpRx does not affect that pricing.
Pharmacies Are Not Required to Participate
The coupons generated through TrumpRx are manufacturer discount programs, not government mandates. Individual pharmacies can choose whether to accept them. In practice, major chains typically honor manufacturer coupons, but it is worth confirming with your pharmacy before assuming the price will apply.
What About Medicare?
Medicare beneficiaries are a separate situation. The administration has discussed a $50/month copay cap for Medicare Part D patients on certain medications. However, Medicare Part D has historically not covered anti-obesity medications like Wegovy or Zepbound. Legislative efforts (including the TREAT Obesity Act) aim to change that, but coverage is not guaranteed as of March 2026. If you have Medicare, check with your Part D plan directly to confirm whether your specific medication is covered before relying on any copay cap. TrumpRx coupons are a separate program from Medicare Part D.
How TrumpRx Fits the Bigger Picture
GLP-1 pricing has been changing quickly. A year ago, the only affordable path to semaglutide was through compounded versions or insurance. Now, cash-pay programs from manufacturers, the Wegovy pill launch, and TrumpRx have created more brand-name options at lower prices than list.
For someone exploring weight loss medication in 2026, the landscape breaks down into a few paths:
Brand-name with insurance: If your plan covers Wegovy or Zepbound, manufacturer savings cards can bring your copay to around $25/mo. Getting prior authorization takes time, and many plans still exclude weight loss medications, but this is the cheapest path when it works.
Brand-name without insurance is where TrumpRx fits. Cash-pay through NovoCare, LillyDirect, or TrumpRx runs $149-$349/mo for semaglutide (depending on dose and whether you choose the pill or injection) or $299-$449/mo for tirzepatide. Promotional rates for the first two months bring initial costs lower. All of these are FDA-approved medications.
Compounded versions sit outside all of these programs. They are not FDA-approved, not available through TrumpRx, and face increasing regulatory scrutiny since the FDA declared the semaglutide shortage resolved. Pricing ranges from roughly $140-$599/mo through telehealth providers, which can be less than brand-name depending on the dose and provider you choose.
Regardless of path, you need a prescription from a licensed provider. That requirement does not change based on which pricing program you use.
What to Do Next
The sequence for using TrumpRx is straightforward. Start with a provider who prescribes the brand-name medication you want. Get evaluated. If prescribed, use TrumpRx pricing at checkout or present the coupon at your pharmacy.
If you already have a prescription, visit trumprx.gov and search for your medication. The site will either generate a coupon for your pharmacy or redirect you to the manufacturer's online pharmacy where you can fill at the discounted price.
For anyone still weighing brand-name against compounded options, or comparing telehealth providers, our provider comparison covers pricing, program features, and what each one includes. The right provider fit depends on more than just the medication price.
Sources and References
This guide is based on government sources, independent policy analysis, and manufacturer pricing data:
TrumpRx. Official website. Accessed March 12, 2026. trumprx.gov
Kaiser Family Foundation. "TrumpRx: What's the Value for Customers?" Issue Brief. February 24, 2026. KFF.org
NovoCare. Wegovy pricing and savings. Verified March 12, 2026. NovoCare.com
CBS News. "TrumpRx: See the 43 drugs available on the Trump administration's new discounted drug site." February 2026. CBSNews.com
Last updated: March 12, 2026. TrumpRx is a new program and details may change. Verify current pricing and availability at trumprx.gov or with your provider before making treatment decisions.